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Moreover, cancer cells carrying mutations of succinate dehydrogenase, fumarate hydrolase or isocitrate dehydrogenase accumulate -KG competitors including succinate, fumarate and 2-hydroxyglutarate, respectively 43,49,50

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Safety is dose, delivery, and patient selection dependent, so implement mitigation measures including baseline screening, slow dose escalation, and monitoring for immune reactions or aberrant tissue growth

CPT II deficiency The adult CPT II clinical phenotype is somewhat benign and requires additional external triggers such as high-intensity exercise before the predominantly myopathic symptoms are elicited

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