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Summary Keywords topiramate, migraine, oxidative stress, neurogenic inflammation, ferroptosis Citation Chen Q-W, Meng R-T and Ko C-Y (2024) Modulating oxidative stress and neurogenic inflammation: the role of topiramate in migraine treatment

Down-regulation of the K + Cl co-transporter KCC2 has been reported in multiple studies 3,4,5,6,7

This process helps determine whether peptide therapy such as GHK-Cu is clinically appropriate and identifies any potential contraindications or risk factors before initiating treatment

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In vitro studies, preclinical studies, retrospective studies and randomized clinical trials performed in Europe and the USA were included

doi: 10.1042/bj3320097