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In mammals, the GPxs family consists of eight members (GPx1-GPx8) identified so far

Saiyin W, Wang D, Li L, Zhu L, Liu B, Sheng L, et al

The deacetylase BshB1 catalyzes deacetylation of GlcNAc-Mal to GlcN-Mal

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The subsequent antigen presentation triggers the activation of Th1 and Th17 cells, leading to the release of pro-inflammatory cytokines (IL-2, TNF-, IFN-, IL-17), which in turn amplify oxidative stress and perpetuate an amplifying loop of inflammation and tissue damage (Kubiak et al

however, the relationship between HOXA2 methylation and CKD-related fibrosis remains unknown