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Over a period of 6 months, patients lost an average of 12.8 kg, 11.3 kg, and 6.7 kg on the 1 mg, 0.5 mg, and 0.25 mg doses, respectively, as compared to a 2.2 kg weight loss in the placebo group [76]

With a 20-day active period and 4 months off, the total annual protocol commitment is 60 active days spread across the year

And so, while those basic-science lab studies and animal studies are promising, before we can really see if the hope matches the hype, weve got to see some additional research. Spittler agreed

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The cornerstone of therapy has traditionally been through vitamin B12 replacement, which helps restore red blood cell production and improve neurological function

Approach injectable forms cautiously due to absent dosing standardization and regulatory approval