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If you're experiencing purging, the counterintuitive solution is often to continue use

Lam M, Pereira AAL, Marie PK, Davis JS, Yu RX, Morris J, Manyam GC, Broom BM, Maru DM, Katkhuda R, Menter D, Kopetz S

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Challenges of usage of glutamine, it is much more expensive and naturalistic, so it is reasonable to consider its usage only after the optimization of HU therapy and not at the risk of reducing adherence to HU and use it as a primary therapy for those who tolerate HU poorly [20]

GR is a flavo-protein oxidoreductase ubiquitously present in both prokaryotes and eukaryotes (Romeo-Puertas et al., 2006)