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The increased oxidation of estrogens does not seem to result in increased estrogen DNA-adduct formation, suggesting that these molecules do not mediate the carcinogenic effect of COCs

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2013 Mar;61(3):233-9.

POR is widely expressed in the endoplasmic reticulum and donates electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYPs) and other proteins[30]