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Here, we employed AlphaFold2, molecular dynamics (MD) simulations, ZDOCK and Rosetta to accurately estimate nanobody stability and affinity change upon ncAA mutation (Fig

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Maintenance phase: Some practitioners drop to 250 mcg every other day during maintenance phases to sustain modest lipolytic tone without driving full receptor engagement daily

Inflammation panel, Olink) and hsCRP were analyzed using multivariable Cox regression adjusted for cardiovascular risk factors

To bridge this translational gap, future research should incorporate advanced platforms, including patient-derived induced pluripotent stem cell (iPSC) models, aged brain organoids, and computational models of disease progression, to more accurately assess the therapeutic potential of natural products