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This is achieved through the formation of mitochondrial and endoplasmic reticulum contact sites (Oanh et al., 2017)

Besides, there is increased oxidation of protein, lipid, and DNA due to depletion of dietary antioxidants, protein stores, and systemic inflammation in CKD [71, 72]

Metabolism-based drug discovery in zebrafish: an emerging strategy to uncover new anti-seizure therapies

Alternatively, glutathione can be quantified after reduction of GSSG in the sample with dithiotreitol (DTT) and subsequent derivatization of GSH with mbrB or mchlB via a reverse-phase high-performance liquid chromatography (HPLC) system equipped with a fluorescent or UV detector, or spectrophotometrically after a GR-mediated glutathione recycling assay (total glutathione) from cell organelles after isolation or fractionation

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