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Commercial pressure would probably also be one of the reasons

In some embodiments, the formulation or composition provides a 0.25:1 ratio, or a 0.5:1 ratio, or a 1:1 ratio, or a 1:2 ratio, or a 1:3, or a 1:4 ratio, or a 1:5 ratio, or a 1:7 ratio, or a 1:10 ratio, or a 1: 15 ratio, or a 1:20 ratio of immediate release and extended release formulations or compositions of a first otic agent and second therapeutic agent, respectively

(iii) Superoxide also interacts with nitric oxide, which is formed in large quantities in the brain by an enzyme neuronal NO synthase (nNOS)

Oh, that I've heard that

However, an association does not prove that low glutathione caused the problem or that a supplement will correct it

Clinical pharmacology and therapeutic use of pyridostigmine