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Bacterial resistance is primarily mediated by beta-lactamase enzymes that hydrolyze the beta-lactam ring, rendering the antibiotic ineffective

These AG 538 bioisosteres possessed similar but weaker biological properties to AG 538 but are more stable and blocked the formation of colonies of prostate and breast cancer cells in soft agar systems (Blum et al, 2003)

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Based on the clinical trial data and the known mechanism, AOD 9604 does not appear to cause muscle loss

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BPC-157 (Body Protection Compound) is a synthetic pentadecapeptide derived from a protective gastric protein