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G.HuangL.et al (2024)

Several researchers reported that oxidative stress can lower producing endothelial NO that can increase the smooth muscle tone, induce vasodilation, and diminish the ability of the penis to achieve an erection [221,222]

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While current clinical and basic evidence strongly supports ferroptosis as a key contributing mechanism in periodontitis progression, the extent of its role relative to classical pathogenic factors such as dysbiosis and immune dysregulation, as well as its causal temporality in the natural history of the disease, remains unclear