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It has to be noted however that gain of function may also develop in parallel with loss of function, with reactive astrocytes for example losing their ability to clear glutamate in the context of motor neurone diseases

In addition, aberrant Ca 2+ signaling causing mitochondrial dysfunction can adversely affect neurotransmitter signaling and lead to excitation/inhibition imbalance [94, 97, 98]

Supports Immune Cells When we think about immune function, we generally go to things like vitamin C, vitamin D, zinc, and maybe even selenium, but we often forget that antioxidants play a significant role in supporting immune defenses

doi: 10.1016/j.jpsychires.2013.01.015 169 StubbsG.HenleyK.GreenJ

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This is most relevant at the thigh and abdomen in lean patients