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Polymeric delivery systems for nucleic acid therapeutics: approaching the clinic

A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2

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Badar T, Kantarjian HM, Ravandi F, Jabbour E, Borthakur G , Cortes JE, Pemmaraju N, Pierce SR, Newberry KJ, Daver N, Verstovsek S