Additionally, in order to explore the mechanism of action being neuronal apoptosis, the research team assessed levels of neuroinflammation and glial activation by detecting levels of IL-1-beta, IL-10, and TNF-alpha in the brain
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Mechanism of Action: Dutasteride is a 5-alpha reductase inhibitor, which inhibits the conversion of testosterone to the more active metabolite 5-dihydrotestosterone (DHT)
COX-2 suppression has been documented in skin inflammation models, adding prostaglandin pathway modulation to the mechanism picture
Cycle length: 812 weeks is the standard cycle, followed by a 46 week break