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By day 28, the hematocrit of mice receiving the dual-modified mEpo mRNA (25% m 5 C + 25% s2U) rose to 64.2 5.9%, which was significantly higher than that of mice receiving unmodified mRNA (54.2 0.5%), modified mRNA containing 50% s2U (56%), or untreated animals (51.5 1%)

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