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11.2 Designer probiotics and synthetic biology innovations While the application of probiotics to address health issues has a long history, contemporary breakthroughs in culturomicsnotably through gnotobiotic animal modelshave catalyzed the evolution of a novel scientific frontier dedicated to engineering host-specific probiotic therapeutics (537)

It acts by selectively binding to HGF receptor, c-Met, leading to the activation of signaling pathways that enhance neuronal function, cognitive function and synaptic connectivity therein

This is the significance of the existence of the BBB (6, 19)

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