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The interaction was also disrupted by tumor-associated mutations in the -domain of pVHL and loss of interaction was associated with defective HIF-1 ubiquitination and regulation, defining a mechanism by which these mutations generate a constitutively hypoxic pattern of gene expression promoting angiogenesis [8487]

10.1038/368502a0 23 BensonM

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In the event of an immediate adverse reaction during intravenous infusion, the administration of the drug should be interrupted immediately and, if possible, the unused remaining liquid should be saved for examination