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Studies have shown that TBI is an environmental risk factor for neurodegenerative diseases including Alzheimers disease (AD) and other dementias (4, 5) while those with repeated head trauma are at risk of developing chronic traumatic encephalopathy (CTE) (6)

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Therefore, the simplest nicotinamide nucleotide analogue system, 1-methylnicotinamide (MNA + , the oxidized form), and 1-methyldihydronicotinamide (MNAH, the reduced form) was used as comparison redox couple