Also it is only in recent years that the lack of efficacy of NUC therapy to lower HCC risk when withheld until later on in the disease was more widely known in the medical community
Hierarchy of Evidence: Level A (Human meta-analyses and systematic reviews of CNS drug delivery)
It may be that there are general dietary (precursor amino acids and purines are both high in many foods), hydration, hepatic, or other influences that affect purines and indoleamines and TYR similarly
Kwon DH, Cha HJ, Lee H, Hong SH, Park C, Park SH, Kim GY, Kim S, Kim HS, Hwang HJ, Choi YH
[Source: Nutritional Science Database] | Glutathione levels naturally decline with age, impacting skin health and detoxification capacity
This provides higher bioavailability