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Morgan AS, Ciaccio PJ, Tew KD and Kauvar LM

Blood 112(11):870, 2008

Millions of people live with this chronic autoimmune condition, watching their skin cycle through painful flares and brief periods of calm

Individuals may find they are intolerant of certain foods although this is not usually a true allergy

By kinetic analysis of single, double, and triple mutants, as well as from studies of reaction products, it was established that the enzyme A216H catalyzes the hydrolysis of the thiol-ester substrate by a mechanism that includes an acyl intermediate at the side chain of Y9