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Data primarily derived from animal studies and early experimental trials

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doi: 10.1186/s13046-025-03303-z 75 WangJYangPYuTGaoMLiuDZhangJet al

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Electrophilic phytochemicals, such as SFN, modify distinct cysteine residues from those affected by oxidative stress [24], allowing the phytochemicals to further upregulate NRF2 activity and mitigate adverse outcomes of external insults [28, 29]

Table 1 Mechanistic studies of inflammation and oxidative stress in osteoporotic bone remodeling