The experimental protocol was approved by the Local Committee for Ethics in Animal Research in Bydgoszcz, Poland (decision number 41/2021)
59,60,366,367,368 According to previous studies by our group, in the absence of SERT, SSRIs such as fluoxetine can act as direct agonists of astrocytic 5-HT 2B receptors to exert antidepressant-like effects
Although early findings generated enthusiasm regarding DSIP's potential therapeutic applications, the current body of evidence is limited and often conflicting
This includes integrating the latest clinical trial data and delving into potential signaling pathways and pharmacological mechanisms
Contraindications include epilepsy, severe renal impairment, and known hypersensitivity to the compound
Atuao Dupla: ao localizada (BPC-157) e sistmica (TB-500)