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doi:10.1186/s12906-018-2101-4

Macrophages in organ fibrosis: From pathogenesis to therapeutic targets

In an extended review, it was highlighted that some preclinical gene-therapy approaches delivering exogenous antioxidant enzymes, via viral vectors or nanozyme platforms, in animal models of hyperglycemic bone defects, significantly reduced inflammation, limited ROS-mediated damage, and improved healing outcomes (Li et al., 2024)

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Preclinical studies suggest that TB-500 peptide may support cell migration during this stage and BPC-157 may support tendon healing processes