Medicines which can decrease the absorption of Vitamin B12 include: Colchicine (a medicine used to treat gout) Metformin (an anti-diabetic agent) Excessive Alcohol Vitamin C products

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Transcription factor activity changes: GHK-Cu modulates activity of key transcription factors including NF-B (inflammation master regulator), AP-1 (stress response), Nrf2 (antioxidant response element activator), p53 (cell cycle and apoptosis regulator)