Activation of FXR in dendritic cells, macrophages, and natural killer T (NKT) cells suppresses the NF-B and NLRP3 inflammasome pathways, thereby attenuating the secretion of pro-inflammatory cytokines (e.g., TNF-, IL-6, and IL-1) while promoting the release of the anti-inflammatory mediator IL-10
A 2014 review by Seiwerth and colleagues in Current Pharmaceutical Design summarized the preclinical vascular effects attributed to BPC-157 and framed the mechanistic hypotheses that subsequent studies have tested
Healthcare providers should maintain open communication about all treatments patients are using and provide evidence-based guidance prioritizing interventions with established safety and efficacy profiles
Interestingly, protective baseline microbiome signatures were identified in stress-resilient rodents
Injections are administered subcutaneously, typically in abdominal fat or other convenient sites
2023;53(1):e2249948