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15,16,17 There have been incredible improvements in the investigation of genetic correlations with autism over the past two decades, ranging from monoclonal gene studies 18 to contemporary large-scale studies using whole-genome sequencing (WGS)

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Concurrently, pivotal metabolic enzymes within the amino acid synthesis pathway, including glutamate-oxaloacetate transaminase 1 (GOT1), glutamate-pyruvate transaminase 2 (GPT2), pyrrolidine-5-carboxylic acid reductase 1 (PYCR1), and phosphoserine aminotransferase 1 (PSAT1), demonstrated increased expression [214]