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The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

Bioinformatics 29 , 1521 (2013)

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Classical CypD inhibitors, such as cyclosporin A and its non-immunosuppressive analogue NIM811, attenuate mitochondrial Ca 2+ overload, preserve m in both acinar and ductal cells, reduce necrosis, and dampen systemic inflammatory responses

PLoS ONE 10 , e0119511 (2015)

Yap et al, 2000)