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We strongly advise patients to exercise caution and consult with our experienced healthcare professionals before considering any unapproved substances or therapies

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Important to consider Physical difficulty: This route is demanding and is not recommended for people with vertigo, mobility problems or limited physical condition

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Administration to animals with diarrhoea