In cultured fibroblasts, GHK-Cu increased collagen synthesis at strikingly low concentrations the effect began between roughly 10 -12 and 10 -11 M and peaked near 10 -9 M, independent of any change in cell number, meaning the peptide upregulated matrix production per cell rather than simply growing more cells
Histological examination showed better granulation tissue formation, improved re-epithelialization, enhanced dermal remodeling, and higher collagen deposition compared to untreated controls
Potential Side Effects and Precautions While glutathione is generally considered safe, certain side effects may occur, particularly with high doses or IV administration: Gastrointestinal Issues: Some people may experience bloating, cramping, or nausea with oral supplements
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May be used to induce a cellular model of thiol oxidative stress