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They handle important jobs like hormone production, immune function, tissue repair, and metabolism

The therapeutic window is longer than the pharmacokinetic half life because receptor occupancy and downstream signaling persist after plasma levels fall below detectable thresholds

[DOI] [PMC free article] [PubMed] [Google Scholar] [25].Butterfield DA, Lange ML

Any folic acid not activated by DHFR may enter circulation as UnModified Folic Acid (UMFA), which has been linked to a variety of possible negative outcomes including derangement of immunity, neurodegeneration, and cancer, although a direct causal link cannot be stated [22]

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