doi: 10.1016/j.jtemb.2019.07.007 95 ChakrabortyMChutiaHChangkakatiR
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Van Haren RM, Correa AM, Sepesi B, Rice DC, Hofstetter WL, Roth JA, Swisher SG , Walsh GL, Vaporciyan AA, Mehran RJ, Antonoff MB
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How This Works Dihexa is a modified dipeptide-like molecule built from the tyrosine-isoleucine core of angiotensin IV , with both termini capped by hexanoic-acid-derived groups that raise lipophilicity and blunt enzymatic degradation the changes that gave it oral activity and blood-brain-barrier penetration [1]
The compound is identical in mechanism to what the research community calls retatrutide or LY3437943