Disclosure of interest: Xiao Wang: nothing to disclose E-Posters - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P2515 - ESOC25-1203 GUT MICROBIOTADEPENDENT TRIMETHYLAMINE N-OXIDE AND COGNITIVE FUNCTION OVER THREE YEARS AFTER MILD-TO MODERATE ISCHEMIC STROKE - PROSCIS B Thomas Liman 1 , Naomi Giesers 2 , Arash Haghikia 3 , Ulf Landmesser 4 , Stanley Hazen 5 , Matthias Endres 6 1 University of Oldenburg, Charit Universittsmedizin Berlin, Oldenburg, Germany, 2 University of Oldenburg, Oldenburg, Germany, 3 Ruhr University Bochum, Bochum, Germany, 4 Charit Universittsmedzin Berlin, Berlin, Germany, 5 Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, United States, 6 Charit Universittsmedizin Berlin, Dept of neurology, Berlin, Germany Background and Aims: Gut microbiotadependent metabolites, in particular trimethylamine n-oxide (TMAO) have been identified as promoters of atherosclerosis
Deficiencies in mitochondrial GR activity have been implicated in various neurodegenerative conditions, aging processes, and metabolic disorders
478 Other Mn II -dependent transcriptional repressors from the DtxR family have been described to have an impact on pathogen virulence (Figure 15A)
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Studies have looked at its effects on tendons, ligaments, muscles, nerves, and the digestive tract
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