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Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, & Miyakawa T

Konopleva M, Walter RB, Faderl S, Jabbour E, Zeng Z, Borthakur G, Ruvolo P, Huang X, Kadia T, Feliu J, Burger J, Andreeff M, Kornblau SM , Estey E, Kantarjian

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These data are in agreement with the well-described association of macrophage-dependent chronic AT inflammation with systemic insulin resistance and with genetic knock out of key inflammatory signalling molecules, scaffolding proteins, or cytokines sufficient to dissociate obesity from insulin resistance 59,60,61,62,63,64,65,66