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Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable

Sharma, A

The clinical evidence is weaker than the skin evidence but reasonable

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The path forward for cortistatin likely requires development of selective analogs with improved pharmacokinetics and a clinically feasible administration route

Pentadecapeptide BPC 157 and its Effects on a NSAID Toxicity Model: Diclofenacinducedgastrointestinal, Liver, and Encephalopathy Lesions