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The number of nucleoli and the expression of nucleolar proteins increased when Rpl15 was overexpressed, and abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis have emerged as hallmarks of the majority of spontaneous cancers 42

doi: 10.1038/nrc2069

This evidence has inspired the ligandin model for vacuolar sequestration of anthocyanins ( 1 ), in which arGSTs are believed to protect the labile anthocyanidins ( 3 ) from degradation and/or guide them from their biosynthetic origin on the cytoplasmic surface of the endoplasmic reticulum to transporters located on the tonoplast membrane 18,19,31

The bloodbrain barriers: novel nanocarriers for central nervous system diseases

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Instead, slowly and gently push the plunger, allowing the water to run down the side of the glass and pool at the bottom