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Furthermore, the absence of standardized formulations complicates dose uniformity and treatment reproducibility, as differences in concentration, excipients, or stability across preparations can materially influence therapeutic efficacy and safety outcomes

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Furthermore, we found that Sec24C overexpression elevated the expression of SLC7A11 at PM level, but the effect was abrogated upon exposure to Brefeldin A (Fig

Additionally, conditions such as severe cardiac or pulmonary insufficiency that lead to reduced peripheral perfusion, lactic acidosis, liver disease, alcohol dependence, or the use of intramuscular contrast agents for radiographic imaging also represent exclusion criteria due to the increased risk of adverse effects, particularly lactic acidosis (80, 121)

This means even people with a B12-rich diet can fall short as they get older