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J Neuroendocrinol 17, 788803 (2005)

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Kross and Scheer, 1991), and the ClO 2 prodrug NaClO 2 has also been approved as an ALS orphan drug by the European medicines agency (EMA) (EU/3/13/1139, 2024), and has demonstrated efficacy in a subset of ALS patients administered NaClO 2 intravenously in a Phase 2B clinical trial, notably reducing LPS levels in the blood which would suggest antimicrobial efficacy (Zhang et al., 2022)

6.5.3 Extremely limited clinical intervention Most current evidence derives from preclinical models, while interventional clinical trials specifically designed to target the ferroptosis pathway in AD patients remain scarce