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According to the NIH Office of Dietary Supplements, vitamin B12 is available as cyanocobalamin and hydroxocobalamin, which are typically administered parenterally by intramuscular injection to bypass gastrointestinal absorption barriers

In deficiency, the body makes abnormally large, inefficient cells (megaloblastic anemia)

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Because the body doesnt store water-soluble vitamins, they need to be consumed daily either via food or a supplement

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This inefficiency means you need to take significantly higher doses to achieve therapeutic levels in your blood, which can be both costly and ineffective