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Thus, the monosaccharides fructose, galactose, and ribose join upstream in the glycolytic pathway of cancer cells that express suitable GLUTs, kinases, or other enzymes favoring uridine catabolism

In contrast, iTregs arise in the periphery, where cytokines such as TGF- and IL-2 promote their antigen-induced Foxp3 expression and suppressive function, thereby establishing tolerance to foreign antigens

458,459 Impaired BCAA catabolism/oxidation is associated with contractile dysfunction and heart failure development, 433 and these metabolic disturbances are linked not only to cardiac dysfunction but also to cardiac remodeling and insulin resistance in heart failure patients

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