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Oxidative stress caused by physical/emotional stress, strenuous exercise, exposure to environmental toxins, and immune stress can all cause an increase in free radicals, which may cause oxidative stress and deplete glutathione

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Ahmad F, Haque S, Ravinayagam V, Ahmad A, Kamli MR, Barreto GE, Ghulam MA (2020) Developmental lead (Pb)-induced deficits in redox and bioenergetic status of cerebellar synapses are ameliorated by ascorbate supplementation

Glial cells Non-neuronal central nervous system cells, including astrocytes and oligodendrocytes, that function to maintain homeostasis, support neurotransmission and neuronal health, and form myelin

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J Psychosomatic Res