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Another mechanism by which the endo/lysosomal compartment can influence APAP-induced hepatotoxicity is through the clearance of damaged mitochondria in a process also called mitophagy, consisting in the degradation of dysfunctional mitochondria by lysosomal proteases upon fusion of the autophagosomes-containing mitochondria with lysosomes, which is discussed in the next section

Within this ligated area, there were three major arcades

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10.1111/cen.13003 Clin Endocrinol (Oxf)

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