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Further phase 3 clinical trials with larger sample sizes are needed to thoroughly assess the immunopathological effects of MMP inhibitors like doxycycline on TB

The latter enrolled 190 patients with obesity (mean age 54.4 years, mean BMI 36.1 kg/m 2 ) and biopsy-proven MASH and moderate-to-severe fibrosis regardless of the presence of T2D, showing a BW reduction of 10.7%, 13.3%, 15.6% and 0.8% at 52 weeks with tirzepatide 5 mg, 10 mg, 15 mg and placebo, respectively 39

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A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic cells