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DM significantly reduces testosterone levels, androgen receptor (AR), and luteinizing hormone receptor (LHR) in the testes due to the downregulation of AR and LHR []

The activation of PGC-1 by SIRT1-mediated deacetylation interacts with mitochondrial transcription factor A (TFAM), then enhancing TFAM coactivation and more efficient mitochondrial DNA (mtDNA) transcription

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Intranasal esketamine has subsequently been approved as an adjunctive treatment for TRD by the TPD, EMA, and TGA and to treat MDD with psychiatric emergency by the TPD and EMA [123,124,125]