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J Clin Psychiatry (2005) 66(Suppl 3):2836

Effect of combination folic acid, vitamin B6 , and vitamin B12 supplementation on fracture risk in women: a randomized, controlled trial

Both compounds are potent antioxidants by themselves, but when combined, they provide a biological feedback loop that increases each one's potency

Because of these factors, its pretty common for patients to stop treatment or not follow through with the full protocol in real-life situations

A postmortem frontal cortex study also showed significant increases in protein and mRNA levels of pro-apoptotic factors and significant decreases in levels of anti-apoptotic factors in BD compared to nonpsychiatric controls [54]

Mild deficiency: Patients with mild B12 deficiency might only need a small dose