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In summary, the study demonstrates that FOXO4-DRI effectively eliminates senescent Leydig cells, improves the testicular microenvironment, and alleviates age-related testosterone secretion insufficiency, highlighting its therapeutic potential for male late-onset hypogonadism [1]

PLoS ONE 10:e0124082 Pillai PS, Molony RD, Martinod K, Dong H, Pang IK, Tal MC, Solis AG, Bielecki P, Mohanty S, Trentalange M (2016) Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

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303 some Wnt inhibitors strengthen the Immune checkpoint blockade (ICB) therapy by combination therapy