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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

CAS Numbers BPC-157: 137525-51-0 GHK-Cu: 49557-75-7 TB500: 885340-08-9 BPC-157 is a 15-amino acid pentadecapeptide (molecular weight: 1,419 Da) modeled after a naturally occurring gastric peptide with structural stability in biological environments