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The PCOS model was established through daily subcutaneous injections of dehydroisoandrosterone (DHEA, 60 mg/kg, LKT Laboratories) over a period of 20 days [20]

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IGF-1 LR3 is often utilized as a model compound to explore how IGF-1 receptor activation impacts cellular aging mechanisms

Researchers found that HR488B (HDACi) induces cell cycle G0/G1 arrest and apoptosis through mitochondrial dysfunction, reactive oxygen species (ROS) generation, and accumulation of DNA damage, thereby specifically inhibiting the growth of CRC cells

The result is an "energy crisis." In chronic cases, neurons enter a state of metabolic depression they are dormant, "idling" cells [5]

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