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Fra-1 overexpression lowered endogenous GCLC expression and rat GCLC promoter activity while Fra-1 antisense has the opposite effects

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These metabolic signatures may serve as stratification biomarkers for FGF21 treatment selection

Current Opinion in Endocrinology, Diabetes, and Obesity, 29 (6), 554-559

Glutamine supports immune cell metabolism, especially lymphocyte proliferation and macrophage function, which makes it a key component in parenteral and enteral nutrition formulations targeting immune function maintenance

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