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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

It has been documented that patients with CD have higher plasma levels of lipid peroxidation products, a decreased peroxidation potential, and an oxidative low-density lipoprotein level, particularly during an active phase of the disease (155)

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Changes in sleep architecture included increased lighter sleep stages (S1 and S2), decreased deep sleep stages (S3, S4), and REM sleep, as well as delayed REM sleep onset