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In some embodiments, the otic formulation or composition comprises between about 0.001% to about 20% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In Vitro Cellular and Developmental Biology

one trial, n = 274

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Johansen and colleagues (10), as a follow-up to the original study conducted by Tonder and others (9) found that intra-ischemic hypothermia (29C) prevented ischemic-induced intracellular zinc accumulation and subsequent cellular demise, likely by inhibiting zinc translocation